Nowadays, the Internet of Bio-NanoThings (IoBNT) is playing an important role to become the leading technique used in healthcare delivery systems. The IoBNT is considered a promising paradigm for efficient communication between nanodevices to deliver therapeutic drug molecules and thus achieve the target concentration to the diseased cell/tissue inside intra-body nanonetworks. However, ignoring the physical architecture of these nanodevices may effect on the delivered concentration when employing the IoBNT paradigm. Therefore, in this paper, we propose a spherical transmitter nanodevice, namely reservoir for controlling the drug molecules to be released and showing the effects of the geometry design of such nanodevice on the concentration arrived inside intra-body nanonetwork. Moreover, we present a pharmacokinetic system comprising of a mathematical model for studying the effects and variance in drug concentration, while taking into consideration the distance from the center of the nanotransmitter to the center of the nanoreceiver. The performance analysis of the proposed IoBNT system is numerically investigated. The performance is evaluated by employing the pharmacokinetic model in terms of bio-cyber interface forward and reverse links. The simulation results reveal that the proposed model is able to achieve a high concentration around the targeted cells and thus decrease side effects around healthy cells compared with the state-of-the-art. Additionally, the results illustrate that proposed reservoir is capable of controlling the emission of the therapeutic drug molecules and thus improving the delivery of the dose at target time.

如今，生物纳米材料互联网（IoBNT）扮演着重要角色，成为医疗保健配送系统中使用的领先技术。IoBNT被认为是在纳米设备之间进行有效通信以传递治疗药物分子并因此达到体内纳米网络内部患病细胞/组织的目标浓度的有希望的范例。但是，在采用IoBNT范例时，忽略这些纳米设备的物理体系结构可能会影响所传递的浓度。因此，在本文中，我们提出了一种球形发射器纳米器件，即用于控制要释放的药物分子的储器，并展示了这种纳米器件的几何设计对到达体内纳米网络内部浓度的影响。此外，我们提出了一个药代动力学系统，其中包括一个数学模型，用于研究药物浓度的影响和方差，同时考虑了从纳米发射器中心到纳米接收器中心的距离。数值研究了所提出的IoBNT系统的性能。通过采用药代动力学模型对生物网络界面的正向和反向链接进行评估。仿真结果表明，与现有技术相比，所提出的模型能够在靶细胞周围实现高浓度，从而减少健康细胞周围的副作用。另外，