We aimed to study the mortality among hospitalized patients with systemic lupus erythematosus (SLE). We performed a retrospective cross-sectional study and identified patients with SLE who were hospitalized at Jordan University Hospital (JUH) between 2002 and 2017.There were 990 admissions among which 283 were SLE patients. The mean age at disease onset was 34 ± 12.5 years and the female to male ratio was 8.4:1. Forty patients died during the 15-year period. In-hospital case fatality was 14% over 15 years. For the deceased patients, the female to male ratio was 3.4:1, mean age at disease onset was 27.8 ± 11.5 years, mean age at death was 35.1 ± 12 years, and mean disease duration was 7.5 ± 6.9 years. Twenty patients had disease duration ≤ 5 years. Infection and SLE-related complication contributed equally to mortality in hospitalized SLE patients (42.5% [CI 27.5%–59%] and 40% [95% CI 25%–56.5%], respectively). Infection related mortality compared to SLE-related mortality was associated with younger age and shorter disease duration (29.5 years versus 38.3 years and 6.4 versus 8.7 years, respectively). CRP was higher in infection related mortality compared to SLE-related mortality (131.4 mg/dl versus 87.6 mg/dl, respectively). Most SLE-related deaths were secondary to pulmonary disease. Renal disease did not contribute directly to mortality. No fatalities were attributed to cardiovascular disease (CVD) or cancer. Infection and active SLE accounted for the majority of deaths at a young age. Significant pulmonary related deaths may indicate a change in trends in SLE mortality, as renal related mortality is expected to decline due to proper management.

我们旨在研究系统性红斑狼疮（SLE）住院患者的死亡率。我们进行了一项回顾性横断面研究，确定了2002年至2017年期间在约旦大学医院（JUH）住院的SLE患者。共收治990例患者，其中283例为SLE患者。发病的平均年龄为34±12.5岁，男女之比为8.4：1。在15年中，有40名患者死亡。在15年中，医院内的病死率为14％。对于死者，男女之比为3.4：1，平均发病年龄为27.8±11.5岁，平均死亡年龄为35.1±12岁，平均病程为7.5±6.9岁。20名患者的病程≤5年。感染和与SLE相关的并发症同样对住院SLE患者的死亡率做出了贡献（分别为42.5％[CI 27.5％–59％]和40％[95％CI 25％–56.5％]）。与SLE相关的死亡率相比，感染相关的死亡率与年龄较小和疾病持续时间较短有关（分别为29.5岁对38.3岁和6.4对8.7岁）。与感染相关的死亡率相比，CRP高于SLE相关的死亡率（分别为131.4 mg / dl和87.6 mg / dl）。大多数与SLE相关的死亡是继发于肺部疾病。肾脏疾病并没有直接导致死亡。没有死亡可归因于心血管疾病（CVD）或癌症。感染和活跃的SLE占年轻死亡的大部分。大量与肺有关的死亡可能表明SLE死亡率趋势发生了变化，