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Cerebral hemodynamics associated with fluid-attenuated inversion recovery hyperintense vessels in patients with extracranial carotid artery stenosis.
Neuroradiology ( IF 2.4 ) Pub Date : 2020-03-09 , DOI: 10.1007/s00234-020-02385-0
Takuma Nishimoto 1 , Hideyuki Ishihara 1 , Fumiaki Oka 1 , Mototsugu Shimokawa 2 , Michiyasu Suzuki 1
Affiliation  

PURPOSE Fluid-attenuated inversion recovery hyperintense vessels (FHVs) are linked to sluggish or disordered blood flow. The purpose of this study is to compare FHVs with digital subtraction angiography (DSA) findings and cerebral hemodynamic changes on acetazolamide challenge SPECT and to determine the clinical and imaging metrics associated with FHVs in patients with extracranial carotid artery stenosis (ECAS). METHODS The subjects were patients with chronic ECAS who underwent carotid artery stenting in our department between March 2011 and October 2018. Relationships of FHVs with age, sex, medical history, cerebral angiographic findings using DSA, and quantitative values of cerebral blood flow (CBF) were examined. The resting CBF (rCBF) and cerebrovascular reactivity (CVR) in the middle cerebral artery territory were measured quantitatively using SPECT with acetazolamide challenge. We used multivariate logistic regression analysis to identify independent predictors of FHVs. RESULTS Of 173 patients included, 92 (53.2%) had FHVs. Patients with FHVs had more severe stenosis (P < 0.01) and more leptomeningeal collateral vessels (P < 0.01). FHV-positive cases had significantly reduced CVR compared with FHV-negative cases (P < 0.01), although there was no significant difference in rCBF between FHV-positive and FHV-negative cases. Logistic regression analysis showed that ipsilateral rCBF and ipsilateral CVR were significant predictors for FHVs (P < 0.01). CONCLUSION In patients with ECAS, cerebral hemodynamic metrics, especially ipsilateral rCBF and ipsilateral CVR, are associated with the presence of FHVs.

中文翻译:

颅外颈动脉狭窄患者的脑血流动力学与液体衰减型反转恢复高强度血管相关。

目的减液的反转恢复高强度血管(FHV)与缓慢或无序的血流有关。这项研究的目的是比较FHVs与数字减影血管造影(DSA)的发现以及乙酰唑胺攻击SPECT的脑血流动力学变化,并确定颅外颈动脉狭窄(ECAS)患者中与FHV相关的临床和影像学指标。方法研究对象为2011年3月至2018年10月在我科行颈动脉支架置入术的慢性ECAS患者。FHV与年龄,性别,病史,使用DSA进行脑血管造影检查结果以及脑血流(CBF)定量值的关系被检查。大脑中动脉静息CBF(rCBF)和脑血管反应性(CVR)使用SPECT和乙酰唑胺激发定量测定。我们使用多元逻辑回归分析来确定FHV的独立预测因子。结果在173例患者中,有92例(53.2%)患有FHV。FHV患者的狭窄程度更高(P <0.01),软脑膜侧支血管更多(P <0.01)。与FHV阴性病例相比,FHV阳性病例的CVR显着降低(P <0.01),尽管FHV阳性病例与FHV阴性病例的rCBF没有显着差异。Logistic回归分析显示,同侧rCBF和同侧CVR是FHV的重要预测因子(P <0.01)。结论对于ECAS患者,其脑血流动力学指标,
更新日期:2020-03-09
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