PURPOSE To investigate the diagnostic capability of scleral spur length in discriminating eyes with primary open-angle glaucoma (POAG) from healthy eyes. METHODS Seventy-eight eyes of 78 patients with POAG and 93 eyes of 93 age-, sex- and axial length-matched healthy subjects were included. The scleral spur length was measured using swept-source optical coherence tomography. Receiver operating characteristic (ROC) curves were derived based on the measurements. RESULTS The scleral spur length was significantly shorter in POAG eyes compared with healthy eyes (Method I, 164.91 ± 23.36 vs. 197.60 ± 25.32 μm; Method II, 145.15 ± 16.59 vs. 166.95 ± 19.31 μm; Method III, 162.33 ± 22.83 vs. 185.12 ± 23.58 μm, respectively; all p < 0.001). The areas under ROC curves were 0.841 (Method I), 0.810 (Method II), and 0.753 (Method III) for the scleral spur length. Moreover, Schlemm's canal area was significantly associated with the scleral spur length (Method I) in both POAG (β = 0.027; p < 0.001) and healthy (β = 0.016; p = 0.009) groups. CONCLUSIONS The scleral spur length had a good discriminating capability between POAG and healthy eyes, and it could be a novel biomarker for POAG evaluation clinically.

中文翻译：

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原发性开角型青光眼巩膜骨刺长度的诊断能力。

目的 研究巩膜骨刺长度在鉴别原发性开角型青光眼 (POAG) 眼与健康眼中的诊断能力。方法 78例POAG患者的78只眼和93名年龄、性别和轴长匹配的健康受试者的93只眼被纳入。使用扫描源光学相干断层扫描测量巩膜骨刺长度。接受者操作特征（ROC）曲线是基于测量得出的。结果 与健康眼相比，POAG 眼的巩膜骨刺长度显着缩短（方法 I，164.91 ± 23.36 对 197.60 ± 25.32 μm；方法 II，145.15 ± 16.59 对 166.95 ± 19.31 μm，16 对 223 ±3223）分别为 185.12 ± 23.58 μm；所有 p < 0.001）。ROC 曲线下的面积为 0.841（方法 I）、0.810（方法 II）和 0。753（方法 III）用于巩膜骨刺长度。此外，施累姆氏管面积与 POAG（β = 0.027；p < 0.001）和健康（β = 0.016；p = 0.009）组的巩膜骨刺长度（方法 I）显着相关。结论巩膜骨刺长度对POAG与健康眼有较好的区分能力，可作为临床评价POAG的新型生物标志物。