Purpose

This study aimed to explore the differences in VERDICT parameters for normal prostatic tissues among different regions and age groups.

Materials and methods

In total, 31 male volunteers were included in the study. Vascular, extracellular and restricted diffusion for cytometry in tumors (VERDICT) model parameters (fIC, intracellular volume fraction; fEES, extracellular-extravascular space fraction; and fVASC, vascular fraction) were calculated based on the whole prostate volume and the peripheral zone (PZ), central gland (CG) and anterior fibromuscular stroma (AS) regions of interest (ROIs). Agreement between two readers was determined by calculating the intraclass correlation coefficient. Two-way ANOVA was used to identify significant differences among age groups and regions within the prostate. Age-related and area-related changes in these parameters were assessed using Spearman’s correlation coefficients.

Results

There were differences in the parameters among regions of the prostate (P < 0.05). In the PZ, there was a negative correlation between age and fIC (r = − 0.66, P < 0.001, adjusted P < 0.001), and age was positively correlated with fEES (r = 0.69, P < 0.001, adjusted P < 0.001) but had no correlation with fVASC. In the CG ROI, there was a positive correlation between age and fEES (r = 0.56, P < 0.001, adjusted P < 0.001) but no correlation between age and fVASC, similar to the results for the PZ. There were no correlations between age and VERDICT parameters in the AS.

Conclusion

VERDICT parameters vary among different regions of the prostate and correlate with age. These findings are in agreement with histological theory.

中文翻译：

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正常前列腺组织的年龄相关和区带解剖显微结构特征：利用VERDICT MRI进行的初步研究。

目的

这项研究旨在探讨不同地区和年龄组的正常前列腺组织VERDICT参数的差异。

材料和方法

该研究总共包括31名男性志愿者。基于整个前列腺体积和外周区（PZ）计算用于肿瘤细胞计数的血管，细胞外和限制扩散（VERDICT）模型参数（fIC，细胞内体积分数; fEES，细胞外血管外空间分数; fVASC，血管分数） ），中枢腺（CG）和前纤维肌基质（AS）感兴趣区域（ROIs）。通过计算组内相关系数确定两个读者之间的一致性。双向方差分析用于确定年龄组和前列腺内区域​​之间的显着差异。使用Spearman相关系数评估这些参数中与年龄相关和与区域相关的变化。

结果

前列腺区域之间的参数存在差异（P  <0.05）。在PZ中，年龄与fIC之间呈负相关（r  = − 0.66，P  <0.001，调整后的P  <0.001），年龄与fEES正相关（r  = 0.69，P  <0.001，调整后的P  <0.001）但与fVASC没有相关性。在CG ROI中，年龄与fEES之间存在正相关（r  = 0.56，P  <0.001，调整后的P  <0.001），而年龄与fVASC之间没有相关性，类似于PZ的结果。在AS中，年龄与VERDICT参数之间没有相关性。

结论

VERDICT参数在前列腺的不同区域之间变化，并且与年龄相关。这些发现与组织学理论一致。