Background

The main aim of this study was to investigate the percentage of individuals who developed long-term disabilities after chikungunya virus (CHIKV) disease on the basis of follow up time interval and its associated risk factors.

Method

In this meta-analysis, electronic databases PubMed, Science Direct and Google Scholar were searched to identify cohort studies of CHIKV disease from January 2000 to June 2018. Total 28 eligible studies were selected for analysis. The pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures were calculated using a random effects model.

Result

Among 28 studies, 24 studies were used for PR calculation and the PR for the long-term disabilities of CHIKV disease patients were found 39.70%, [95% CI: (31.77–47.64), p < 0.01] for follow up time between 6 and 12 months, 35.85%, [95% CI: (24.09–47.61), p < 0.01] for follow up time between 12 and 18 months and 28.20%, [95% CI: (19.74–36.66), p < 0.01] for greater than 18 months respectively. Eighteen studies were used for RR calculation and significant association were found between long-term disabilities after CHIKV disease and gender [RR: 1.46, p < 0.01], age [RR: 1.61, p < 0.01], diabetes [RR: 1.40, p < 0.01], hypertension [RR: 1.37, p < 0.01], severity of pain at acute stage [RR: 2.02, p < 0.01].

Conclusion

Approximately 40% patients developed long-term disabilities after 6 months of CHIKV disease and 28% patients still suffer from this disease after 18 months of acute infection.

中文翻译：

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基孔肯雅病毒病后长期残疾的患病率和危险因素：一项荟萃分析。

背景

这项研究的主要目的是根据随访时间间隔及其相关的危险因素，调查在基孔肯雅病毒（CHIKV）疾病后发展成长期残疾的个体百分比。

方法

在这项荟萃分析中，搜索了电子数据库PubMed，Science Direct和Google Scholar，以鉴定2000年1月至2018年6月之间CHIKV疾病的队列研究。共选择了28项合格研究进行分析。使用随机效应模型计算两种效应量度的合并患病率（PR），风险比（RR）和95％置信区间（CI）。

结果

在28项研究中，有24项研究用于PR计算，发现CHIKV疾病患者长期残疾的PR为39.70％，[95％CI：（31.77-47.64），p <0.01]，随访时间在6到6和12个月的随访时间为35.85％，[95％CI：（24.09-47.61），p <0.01]，随访时间为28.20％，[95％CI：（19.74-36.66），p <0.01]分别超过18个月。18项研究用于RR计算，发现CHIKV病后长期残疾与性别[RR：1.46，p <0.01]，年龄[RR：1.61，p <0.01]，糖尿病[RR：1.40，p之间有显着相关性<0.01]，高血压[RR：1.37，p <0.01]，急性期疼痛的严重程度[RR：2.02，p <0.01]。

结论

大约40％的患者在CHIKV病六个月后发展为长期残疾，而28％的患者在急性感染18个月后仍患有该疾病。