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Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology.
Phytomedicine ( IF 6.7 ) Pub Date : 2020-03-08 , DOI: 10.1016/j.phymed.2020.153201 Md Abdul Hannan 1 , Abdullah Al Mamun Sohag 2 , Raju Dash 3 , Md Nazmul Haque 4 , Md Mohibbullah 5 , Diyah Fatimah Oktaviani 3 , Md Tahmeed Hossain 2 , Ho Jin Choi 3 , Il Soo Moon 3
Phytomedicine ( IF 6.7 ) Pub Date : 2020-03-08 , DOI: 10.1016/j.phymed.2020.153201 Md Abdul Hannan 1 , Abdullah Al Mamun Sohag 2 , Raju Dash 3 , Md Nazmul Haque 4 , Md Mohibbullah 5 , Diyah Fatimah Oktaviani 3 , Md Tahmeed Hossain 2 , Ho Jin Choi 3 , Il Soo Moon 3
Affiliation
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BACKGROUND
Marine algae are rich in some unique biologically active secondary metabolites having diverse pharmacological benefits. Of these, sterols comprise a group of functional lipid compounds that have attracted much attention to natural product scientists.
PURPOSE
This review was aimed to update information on the health effects of algae-derived phytosterols and their molecular interactions in various aspects of human health and diseases and to address some future perspectives that may open up a new dimension of pharmacological potentials of algal sterols.
METHODS
A literature-based search was carried out to retrieve published research information on the potential health effects of algal phytosterols with their pharmacological mechanisms from accessible online databases, such as Pubmed, Google Scholar, Web of Science, and Scopus, using the key search terms of 'marine algae sterol' and 'health potentials such as antioxidant or anti-inflammatory or anti-Alzheimer's or anti-obesity or cholesterol homeostasis or hepatoprotective, antiproliferative, etc.'
RESULTS
Phytosterols of marine algae, particularly fucosterol, have been investigated for a plethora of health benefits, including anti-diabetes, anti-obesity, anti-Alzheimer's, antiaging, anticancer, and hepatoprotection, among many others, which are attributed to their antioxidant, anti-inflammatory, immunomodulatory and cholesterol-lowering properties, indicating their potentiality as therapeutic leads. These sterols interact with enzymes and various other proteins that are actively participating in different cellular pathways, including antioxidant defense system, apoptosis and cell survival, metabolism, and homeostasis.
CONCLUSION
In this review, we briefly overview the chemistry, pharmacokinetics, and distribution of algal sterols, and provide critical insights into their potential health effects and the underlying pharmacological mechanisms, beyond the well-known cholesterol-lowering paradigm.
中文翻译：
海藻的植物甾醇：深入了解潜在的健康益处和分子药理学。
背景技术海藻富含一些具有多种药理益处的独特生物活性次生代谢物。其中，甾醇是一组功能性脂质化合物，引起了天然产物科学家的广泛关注。目的本综述旨在更新有关藻类植物甾醇对健康的影响及其在人类健康和疾病各个方面的分子相互作用的信息，并提出一些可能开辟藻类甾醇药理潜力新维度的未来观点。方法 基于文献的检索，使用关键检索词从可访问的在线数据库（例如 Pubmed、Google Scholar、Web of Science 和 Scopus）中检索已发表的关于藻类植物甾醇的潜在健康影响及其药理机制的研究信息。 “海藻甾醇”和“健康潜力，如抗氧化、抗炎、抗阿尔茨海默氏症、抗肥胖、胆固醇稳态、保肝、抗增殖等”。结果海洋藻类的植物甾醇，特别是岩藻甾醇，已被研究具有多种健康益处，包括抗糖尿病、抗肥胖、抗阿尔茨海默氏症、抗衰老、抗癌和保肝等，这归因于它们的抗氧化剂、抗炎、免疫调节和降低胆固醇的特性，表明它们作为治疗先导药物的潜力。这些甾醇与酶和各种其他蛋白质相互作用，这些蛋白质积极参与不同的细胞途径，包括抗氧化防御系统、细胞凋亡和细胞存活、代谢和体内平衡。 结论在这篇综述中，我们简要概述了藻类甾醇的化学、药代动力学和分布，并提供了关于其潜在健康影响和潜在药理机制的重要见解，超越了众所周知的降胆固醇范式。
更新日期：2020-03-09
中文翻译：
海藻的植物甾醇：深入了解潜在的健康益处和分子药理学。
背景技术海藻富含一些具有多种药理益处的独特生物活性次生代谢物。其中，甾醇是一组功能性脂质化合物，引起了天然产物科学家的广泛关注。目的本综述旨在更新有关藻类植物甾醇对健康的影响及其在人类健康和疾病各个方面的分子相互作用的信息，并提出一些可能开辟藻类甾醇药理潜力新维度的未来观点。方法 基于文献的检索，使用关键检索词从可访问的在线数据库（例如 Pubmed、Google Scholar、Web of Science 和 Scopus）中检索已发表的关于藻类植物甾醇的潜在健康影响及其药理机制的研究信息。 “海藻甾醇”和“健康潜力，如抗氧化、抗炎、抗阿尔茨海默氏症、抗肥胖、胆固醇稳态、保肝、抗增殖等”。结果海洋藻类的植物甾醇，特别是岩藻甾醇，已被研究具有多种健康益处，包括抗糖尿病、抗肥胖、抗阿尔茨海默氏症、抗衰老、抗癌和保肝等，这归因于它们的抗氧化剂、抗炎、免疫调节和降低胆固醇的特性，表明它们作为治疗先导药物的潜力。这些甾醇与酶和各种其他蛋白质相互作用，这些蛋白质积极参与不同的细胞途径，包括抗氧化防御系统、细胞凋亡和细胞存活、代谢和体内平衡。 结论在这篇综述中，我们简要概述了藻类甾醇的化学、药代动力学和分布，并提供了关于其潜在健康影响和潜在药理机制的重要见解，超越了众所周知的降胆固醇范式。
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