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Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots
Phytochemistry ( IF 3.2 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.phytochem.2020.112337
Dongdong Zhang 1 , Deqing Ruan 1 , Jingyi Li 1 , Zhaoqiang Chen 2 , Weiliang Zhu 2 , Fujiang Guo 1 , Kaixian Chen 3 , Yiming Li 1 , Rui Wang 1
Affiliation  

Four undescribed sulfur-containing indole alkaloids, isatisindigoticanines H, I and isatindigosides F, G along with three known analogues were obtained from Isatis tinctoria L. roots. Isatisindigoticanines H and I contained an unusual 1-(thiazol-4-yl)butane-1,2,3,4-tetraol moiety while isatindigosides F and G possessed a new 3-[3-(1H-indole-2-yl)azet-2-yl]-1H-indole skeleton. The putative biosynthetic pathways of isatisindigoticanines H, I and isatindigosides F, G are proposed. The isolated compounds showed nitric oxide inhibitory effects with IC50 values ranging from 4.3 to 70.3 μM.

中文翻译:

来自板蓝根的四种未描述的具有一氧化氮抑制活性的含硫吲哚生物碱

四种未描述的含硫吲哚生物碱、板蓝根 H、I 和板蓝皂苷 F、G 以及三种已知的类似物是从板蓝根中获得的。Isatisindigoticanines H 和 I 包含一个不寻常的 1-(thiazol-4-yl)butane-1,2,3,4-tetraol 部分,而 isatindigosides F 和 G 拥有一个新的 3-[3-(1H-indole-2-yl) azet-2-yl]-1H-吲哚骨架。提出了板蓝根苷 H、I 和靛蓝苷 F、G 的假定生物合成途径。分离的化合物显示出一氧化氮抑制作用,IC50 值范围为 4.3 至 70.3 μM。
更新日期:2020-06-01
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