Embryonic stem cells possess fascinating capacity of self-renewal and developmental potential, leading to significant progress in understanding the molecular basis of pluripotency, disease modeling, and reprogramming technology. Recently, 2-cell–like embryonic stem cells (ESCs) and expanded potential stem cells or extended pluripotent stem cells (EPSCs) generated from early-cleavage embryos display some features of totipotent embryos. These cell lines provide valuable in vitro models to study underlying principles of totipotency, cell plasticity, and lineage segregation. In this review, we summarize the current progress in this filed and highlight the application potentials of these cells in the future.

胚胎干细胞具有令人着迷的自我更新和发展潜能，在理解多能性的分子基础，疾病建模和重编程技术方面取得了重大进展。最近，从早期卵裂胚胎产生的2细胞样胚胎干细胞（ESC）和潜在的干细胞或扩展的多能干细胞（EPSC）表现出全能胚胎的某些特征。这些细胞系提供了有价值的体外模型，用于研究全能性，细胞可塑性和谱系分离的基本原理。在这篇综述中，我们总结了该领域的最新进展，并重点介绍了这些电池在未来的应用潜力。