Cells in our body have to divide within a defined tissue space, which in tumors is more restricted than in normal tissue. In this issue of Developmental Cell, Matthews et al. (2020) reveal that oncogenic Ras^V12-mediated cell rounding and cortical stiffening promote cell division under confined conditions that are similar to those in tumors.

中文翻译：

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不要围栏我：癌细胞如何在拥挤的空间中分裂

我们体内的细胞必须在确定的组织空间内分裂，而在肿瘤中，这种组织比正常组织受到的限制更大。在本期《发育细胞》中，Matthews等人。（2020）揭示了致癌的Ras ^V12介导的细胞变圆和皮质变硬在类似于肿瘤的局限条件下促进了细胞分裂。