The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.

中文翻译：

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识别内体运输的信号。

内体区室是控制内吞循环和溶酶体降解之间平衡的主要分选站，其体内平衡正在成为各种神经退行性疾病（例如阿尔茨海默氏病和帕金森氏病）的中心因素。膜运输通常通过不同运输工具识别跨膜蛋白货物中的特定信号来协调。许多不同的蛋白质运输复合物对于序列特异性识别和检索内体货物，将它们回收到其他隔室并抵消平衡运输介导的降解途径所需的默认内体分拣复合物至关重要。在这篇评论中，我们总结了关键的内体运输机制，