Recently, there has been a boom in stem cell research for various applications in biomedical engineering, regenerative medicine, tissue engineering, drug discovery, and artificial organs. It is crucial to maintain a well-controlled environment for stem cell culturing and subsequent differentiation. In this review, we discussed microfluidic devices, overcoming the limitations of conventional cell culture methods to provide new opportunities for stem cell research. We particularly debated methods used for stem cell differentiation into osteogenic, neural, and endothelial cells with respect to microfluidic systems. We concluded our review of microfluidic device-based stem cell targeted differentiation with an overview of the possibilities this cutting-edge technology could bring to the future of medicine.

最近，在生物医学工程，再生医学，组织工程，药物发现和人工器官的各种应用中，干细胞研究蓬勃发展。维持良好控制的环境以进行干细胞培养和随后的分化至关重要。在这篇综述中，我们讨论了微流体装置，克服了常规细胞培养方法的局限性，为干细胞研究提供了新的机会。我们特别辩论了关于微流系统将干细胞分化为成骨细胞，神经细胞和内皮细胞的方法。我们结束了对基于微流体设备的干细胞靶向分化的综述，并概述了这一尖端技术可能为医学的未来带来的可能性。