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Quality evaluation of powdered poppy capsule extractive by systematic quantified fingerprint method combined with quantitative analysis of multi-components by single marker method.
Journal of Pharmaceutical and Biomedical Analysis ( IF 3.1 ) Pub Date : 2020-03-09 , DOI: 10.1016/j.jpba.2020.113247
Yichao Wang 1 , Yue Yu 1 , Guoxiang Sun 1 , Yong Guo 1
Affiliation  

Powdered Poppy Capsule Extractive (PPCE) is largely used as a raw material of Compound Liquorice Tablets, but there are few studies of its quality evaluation or control. In this paper, a novel strategy for quality assessment of PPCE, systematic quantified fingerprint method (SQFM) combined with quantitative analysis of multi-components by a single marker (QAMS) method, was developed and validated. According to the outcome of Pm and the content of codeine and morphine, 41 batches of PPCEs were classified into two classifications by hierarchical cluster analysis, and the samples in one of the categories were obviously inferior to normal in quality. The results demonstrated that the strategy developed in this paper could provide a new method for quality evaluation of PPCE or even other traditional Chinese medicine (TCM).

中文翻译:

通过系统的定量指纹图谱结合单标记法对多组分的定量分析,对罂粟粉的提取物进行质量评估。

罂粟粉胶囊提取物(PPCE)被广泛用作复方甘草片的原料,但对其质量评估或控制的研究很少。本文提出并验证了PPCE质量评估的一种新策略,即系统定量指纹方法(SQFM)结合单标记法(QAMS)对多组分进行定量分析。根据Pm的结果以及可待因和吗啡的含量,通过分层聚类分析将41批次的PPCEs分为两类,其中一个类别的样本质量明显劣于正常。结果表明,本文提出的策略可以为PPCE甚至其他中药(TCM)的质量评价提供一种新方法。
更新日期:2020-03-09
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