Long-term treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat,Brain, Behavior, and Immunity

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Long-term treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat
Brain, Behavior, and Immunity ( IF 8.8 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.bbi.2020.03.001
Francesca Spiga ₁ , Zidong Zhao ₁ , Stafford L Lightman ₁

Affiliation

Highlights • Prolonged MPRED treatment disrupts basal corticosterone ultradian rhythm.• Prolonged MPRED treatment decreases adrenal response to ACTH.• These effects are associated with decreased expression of steroidogenic proteins.• Prolonged MPRED treatment increases adrenal pro-inflammatory cytokine expression.

中文翻译：

合成糖皮质激素甲泼尼龙的长期治疗会影响大鼠的肾上腺类固醇生成功能和对炎症应激的反应

亮点 • 延长 MPRED 治疗会破坏基础皮质酮超电节律。• 延长 MPRED 治疗会降低肾上腺对 ACTH 的反应。• 这些影响与类固醇生成蛋白的表达减少有关。• 延长 MPRED 治疗会增加肾上腺促炎细胞因子的表达。

更新日期：2020-07-01

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