Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure. This review describes the current state of knowledge about the nature of chromatin at telomeres, its functions, and the relation between chromatin structure and TERRA.

中文翻译：

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端粒染色质和TERRA。

端粒中的染色质功能了解甚少，但通常被认为是抑制性的。然而，端粒DNA序列被转录成长的非编码RNA，称为TElomere含重复序列RNA（TERRA）。由于TERRA分子主要位于端粒，因此已经进行了大量研究以了解其功能以及TERRA转录是如何被调控并影响端粒结构的。这篇综述描述了有关端粒上的染色质性质，其功能以及染色质结构与TERRA之间关系的知识的现状。