Highlights • The affective bias test provides new insights into the relationship between mood-related hormones and affective biases in rats.• Treatment with oestradiol, bisphenol A and carbetocin induced significant positive affective biases in both male and female rats, whilst desmopressin induced a positive affective bias in males only.• The opposite effects to oestradiol were found following formestane treatment, inducing a negative affective bias in both sexes.• In male rats, a negative affective bias was developed following treatment with the low dose of progesterone, whilst in females following the higher dose of progesterone.• Testosterone induced a dose-dependent negative affective bias in males, whilst in females there was no effect found. A positive affective bias was developed in both groups following treatment with the high dose of flutamide.

中文翻译：

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使用雄性和雌性大鼠的情感偏差测试研究激素引起的情感状态变化

亮点 • 情感偏见测试为大鼠情绪相关激素与情感偏见之间的关系提供了新见解。• 雌二醇、双酚 A 和卡贝缩宫素治疗在雄性和雌性大鼠中均诱导显着的积极情感偏见，而去氨加压素则诱导了积极的情感偏见仅在雄性中存在偏见。• 福美坦治疗后发现与雌二醇相反的作用，在两性中均引起负面情感偏见。• 在雄性大鼠中，用低剂量黄体酮治疗后产生了负面情感偏见，而在雌性大鼠中较高剂量的黄体酮。• 睾酮在男性中引起剂量依赖性负面情感偏差，而在女性中未发现影响。在用高剂量氟他胺治疗后，两组都出现了积极的情感偏见。