Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple cells within the tumor microenvironment (TME) aiming for tumor progression and metastasis. The concept behind this review is to underscore the multi-tasking roles taken by CXCL12/CXCR4 signaling in tumor metastasis, and to also suggest some strategies to target the activities within this axis.

肿瘤是动态的组织肿块，因此需要连续暴露于宿主细胞，以培养它们为肿瘤生长和转移铺平道路。CXC趋化因子配体12（CXCL12）/ CXC趋化因子受体4型（CXCR4）是实现此目标的关键信号。收集有关该轴内活动的知识将加深我们对该信号的吸引的最重要了解，该信号对于吸引和交叉连接肿瘤微环境（TME）中的多个细胞，旨在促进肿瘤的进展和转移。这篇综述背后的概念是强调CXCL12 / CXCR4信号传导在肿瘤转移中的多任务作用，并且还提出了一些针对该轴内活动的策略。