Abstract A new fluorescent chemosensor (An3) bearing anthracenyl rings was designed and developed for detection of Zn2+. Addition of Zn2+ into An3 gave rise to a fluorescent turn-on response at 424 nm whereas Al3+, Cd2+, Co2+, Cu2+, K+, Mg2+, Zn2+, Ca2+, Fe3+, Mn2+, Ni2+, Pb2+, and Hg2+ did not induce any emission intensity enhancement. Furthermore, the probe exhibited high selectivity toward Zn2+ and a very low detection limit (36 nM) based on chelation-enhanced fluorescence. Theoretical calculations revealed the possible formation of 1:1 and 1:2 complexes between An3 and Zn2+. In bioimaging experiments, the chemosensor displayed low cytotoxicity and good biocompatibility, rendering it an effective tool for fluorescent visualization of Zn2+ in living cells and zebrafish models.

中文翻译：

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一种高选择性荧光蒽基化学传感器，用于在活细胞和斑马鱼中成像 Zn2+

摘要 设计并开发了一种新型的带有蒽环的荧光化学传感器（An3），用于检测Zn2+。将 Zn2+ 添加到 An3 中会在 424 nm 处产生荧光开启响应，而 Al3+、Cd2+、Co2+、Cu2+、K+、Mg2+、Zn2+、Ca2+、Fe3+、Mn2+、Ni2+、Pb2+ 和 Hg2+ 没有引起任何发射强度增强。此外，该探针表现出对 Zn2+ 的高选择性和基于螯合增强荧光的极低检测限 (36 nM)。理论计算表明 An3 和 Zn2+ 之间可能形成 1:1 和 1:2 的复合物。在生物成像实验中，该化学传感器显示出低细胞毒性和良好的生物相容性，使其成为活细胞和斑马鱼模型中 Zn2+ 荧光可视化的有效工具。