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Total synthesis of carbazole alkaloid clausamine E
Tetrahedron ( IF 2.1 ) Pub Date : 2020-03-07 , DOI: 10.1016/j.tet.2020.131110
Takashi Nishiyama , Ayumi Matsuoka , Ryoichi Honda , Tsuyoshi Kitamura , Noriyuki Hatae , Tominari Choshi

In this study, the total syntheses of 1,3,4-trisubstituted carbazole alkaloid clausamine E was accomplished via an eight-step sequence using construction of the 1,4-dioxygenated carbazole framework based on the cyclocarbonylation between 3-iodo-2-(prop-2-enyl)indole and CO (1 atm) in the presence of tributyl(vinyl)tin and a Pd catalyst.



中文翻译:

咔唑生物碱克劳斯敏E的全合成

在这项研究中,使用1,4-二加氧咔唑骨架的构建基于8-碘-2-((-)之间的环羰基化,通过八步顺序完成了1,3,4-三取代咔唑生物碱克劳斯明E的总合成。在三丁基(乙烯基)锡和Pd催化剂存在下,丙-2-烯基)吲哚和CO(1个大气压)。

更新日期:2020-03-09
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