Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the proliferation and differentiation of B cells in the germinal center. In this issue of EMBO Reports, Fernández-Messina et al [1] present evidence of microRNA transfer from T to B cells via exosomes during synapse formation and highlight the crucial role of these exosomes for germinal center formation and the efficient production of antigen-specific antibodies.

中文翻译：

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外泌体占据（生殖的）中心地位。

有效的抗体生产是导致病原体清除和中和的免疫应答过程中的关键步骤。免疫突触是抗原存在下T淋巴细胞和B淋巴细胞之间的接触点，对于启动B细胞在生发中心的增殖和分化是必需的。在本期《 EMBO报告》中，Fernández-Messina等人[1]提供了在突触形成过程中微小RNA通过外泌体从T细胞转移至B细胞的证据，并突出了这些外泌体在生发中心形成和有效产生抗原特异性中的关键作用。抗体。