Several studies from the US and Europe have shown a population-level decline in serum testosterone in men from 1970’s to early 2000’s. However, to the best of our knowledge, no study examining population-level decline in testosterone has been published in more recent years. The study objective was therefore to examine secular trends in testosterone levels among Israeli men in the first and second decades of the twenty-first century, All incident total testosterone performed between1/2006 and 3/2019 among 102,334 male members of a large health organization. A significant (p < 0.001) and prominent trend of age-independent decline in the testosterone levels was recorded during the study period for most age groups. There was a highly significant age-independent decline in total testosterone in the first and second decades of the twenty-first century. The decline was unlikely to be explained by increasing rates of obesity.

中文翻译：

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睾丸激素的长期趋势-大型政府授权医疗机构的发现

来自美国和欧洲的几项研究表明，从1970年代到2000年代初期，男性血清睾丸激素的水平呈下降趋势。然而，据我们所知，近年来没有发表研究睾丸激素水平下降的研究。因此，本研究的目的是研究二十一世纪第一和第二个十年以色列男性睾丸激素水平的长期趋势。在一个大型卫生组织的102,334名男性成员中，所有事件中的总睾丸激素水平在2006年1月1日至2019年3月3日之间进行。对于大多数年龄组，在研究期间，睾丸激素水平均出现显着（p <0.001）显着且独立于年龄的下降趋势。在二十一世纪的前二十年中，总睾丸激素的下降与年龄无关。这种下降不太可能由肥胖率上升来解释。