BACKGROUND Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). However, evidence is still insufficient about the association between dialysis parameters and VC. Thus, this study was to evaluate association of dialysis parameters with VC. METHODS We enrolled 297 ESRD patients undergoing MHD at six distinct centers in Korea. Study participants were categorized into 3 groups by the scoring system of abdominal aortic calcification based on lateral lumbar radiography (no VC group: 0, mild VC group: 1-7 and advanced VC group: 8-24). We compared the features of dialysis parameters according to the severity of VC. Multivariate logistic regression analysis was used to calculate adjusted odd ratios (ORs) and 95% confidence interval (CI) for mild and advanced VC in each haemodialysis parameter (adjusted OR [95% CI]). RESULTS Pooled Kt/V (spKt/V), equilibrated Kt/V (eKt/V), standard Kt/V (stdKt/V) and the proportion of haemodiafiltration were increased along with the severity of VC. Multivariate regression analysis indicated that advanced VC was positively associated with spKt/V (5.27 [1.51-18.41]), eKt/V (6.16 [1.45-26.10]), stdKt/V (10.67 [1.74-65.52]) and haemodiafiltration (3.27 [1.74 to 6.16]). CONCLUSION High dose dialysis and haemodiafiltration were significantly associated with advanced VC.

中文翻译：

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高剂量血液透析和血液透析滤过参数以及与晚期血管钙化的关系。

背景技术在进行维持性血液透析（MHD）的终末期肾病（ESRD）患者中，血管钙化（VC）是心血管疾病的危险因素。但是，关于透析参数与VC之间关系的证据仍然不足。因此，本研究旨在评估透析参数与VC的关联。方法我们在韩国六个不同的中心招募了297名接受MHD治疗的ESRD患者。根据腰椎侧位X线照相法，通过腹主动脉钙化评分系统将研究参与者分为三组（无VC组：0，轻度VC组：1-7，晚期VC组：8-24）。我们根据VC的严重程度比较了透析参数的特征。多元logistic回归分析用于计算每个血液透析参数中轻度和晚期VC的校正后奇数比（OR）和95％置信区间（CI）（校正后OR [95％CI]）。结果合并的Kt / V（spKt / V），平衡的Kt / V（eKt / V），标准Kt / V（stdKt / V）和血液透析滤过率随VC的严重程度而增加。多元回归分析表明，晚期VC与spKt / V（5.27 [1.51-18.41]），eKt / V（6.16 [1.45-26.10]），stdKt / V（10.67 [1.74-65.52]）和血液渗滤（3.27）正相关[1.74至6.16]）。结论高剂量透析和血液透析滤过与晚期VC显着相关。随着VC严重程度的增加，标准Kt / V（stdKt / V）和血液透析滤过的比例增加。多元回归分析表明，晚期VC与spKt / V（5.27 [1.51-18.41]），eKt / V（6.16 [1.45-26.10]），stdKt / V（10.67 [1.74-65.52]）和血液渗滤（3.27）正相关[1.74至6.16]）。结论高剂量透析和血液透析滤过与晚期VC显着相关。随着VC严重程度的增加，标准Kt / V（stdKt / V）和血液透析滤过的比例增加。多元回归分析表明，晚期VC与spKt / V（5.27 [1.51-18.41]），eKt / V（6.16 [1.45-26.10]），stdKt / V（10.67 [1.74-65.52]）和血液渗滤（3.27）正相关[1.74至6.16]）。结论高剂量透析和血液透析滤过与晚期VC显着相关。