The incidence of type 1 diabetes mellitus (T1DM) increased worldwide. The objective of the paper was to compare the incidence trend of T1DM in children and adolescents aged 0–19 and in adults under 30 years of age in Serbia from 2006 to 2017. Additional aim was to compare incidence rates of T1DM and type 2 diabetes mellitus (T2DM) among adults aged 20–24 and 25–29 years of age. Trends and annual percentage change (APC) of the incidence rate with corresponding 95% confidence intervals (CI) were calculated by Joinpoint Regression Analyses. We found a significant increase of incidence in children aged 5–9 with the APC of 5.7% (95%CI: 2.3–9.1), and in children aged 10–14 with the APC of 2.1% (95%CI: 0.6–3.6). A significant decrease of incidence was determined in adolescents aged 15–19 with the APC -4.9% (95%CI: − 8.9 to – 0.7) and in adults aged 25–29 with the APC -7.3% (95%CI: − 12.5 to − 1.8). The increase of incidence in children aged 0–14 and its decrease after 15 years of age showed that T1DM is predominantly a metabolic disease of children in Serbia. A significant increase in incidence was recorded in two age groups, namely 5–9 and 10–14 years of age. The highest increase was in children aged 5–9 and the highest incidence rate was in children aged 10–14. An insignificant increasing of T2DM incidence was observed in young adults aged 25–29. The increase in incidence rates in children, but not in young adults, suggests that the precipitating factors of children-onset disease may differ from those of adult-onset T1DM.

中文翻译：

---

塞尔维亚1型糖尿病发病趋势


全球 1 型糖尿病 (T1DM) 的发病率有所增加。本文的目的是比较 2006 年至 2017 年塞尔维亚 0-19 岁儿童和青少年以及 30 岁以下成人中 T1DM 的发病率趋势。其他目的是比较 T1DM 和 2 型糖尿病的发病率(T2DM) 发生在 20-24 岁和 25-29 岁的成年人中。通过 Joinpoint 回归分析计算发病率的趋势和年度百分比变化 (APC) 以及相应的 95% 置信区间 (CI)。我们发现 5-9 岁儿童的发病率显着增加，APC 为 5.7%（95%CI：2.3-9.1），10-14 岁儿童的 APC 为 2.1%（95%CI：0.6-3.6）。 ）。在 15-19 岁青少年中，APC 为 -4.9%（95%CI：− 8.9 至 – 0.7），在 25-29 岁成人中，APC 为 -7.3%（95%CI：− 12.5），发病率显着下降。至 - 1.8）。 0-14岁儿童发病率上升，15岁后发病率下降，表明T1DM是塞尔维亚儿童的主要代谢性疾病。两个年龄组（即 5-9 岁和 10-14 岁）的发病率显着增加。增幅最高的是5-9岁儿童，发病率最高的是10-14岁儿童。在 25-29 岁的年轻人中观察到 T2DM 发病率无显着增加。儿童发病率增加，但年轻人发病率没有增加，这表明儿童发病的 T1DM 的诱发因素可能与成人发病的 T1DM 不同。