Case of type 2 diabetes possibly caused by excessive accumulation of visceral fat in a child born small-for-gestational age.,Journal of Diabetes Investigation

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Case of type 2 diabetes possibly caused by excessive accumulation of visceral fat in a child born small-for-gestational age.
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-03-26 , DOI: 10.1111/jdi.13246
Remi Kuwabara ₁ , Tatsuhiko Urakami ₁ , Kei Yoshida ₁ , Ichiro Morioka ₁

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We encountered a 12‐year‐old boy with type 2 diabetes who was born small‐for‐gestational age. We described his clinical characteristics and a possible etiological factor for development of hyperglycemia. He developed well with sufficient nutrition and progressed to being overweight at 6 years‐of‐age as a result of a high‐calorie, high‐protein intake diet. He showed a diabetic pattern with a normal insulin response on an oral glucose tolerance test carried out with the urine glucose screening program at schools. He showed a large total fat area of 239.4 cm²; in particular, his visceral fat area was 103.0 cm² with a high ratio of visceral fat area to subcutaneous fat area (0.76). The present case might show that insulin resistance, possibly as a result of accumulation of a great amount of visceral fat, might be attributed to the pathogenesis of type 2 diabetes in children born small‐for‐gestational age.

中文翻译：

一例可能是小于胎龄儿内脏脂肪堆积过多导致的2型糖尿病。

我们遇到了一名患有 2 型糖尿病的 12 岁男孩，他出生时小于胎龄。我们描述了他的临床特征和发生高血糖的可能病因。他发育良好，营养充足，但由于高热量、高蛋白饮食，他在 6 岁时就出现超重。在学校的尿糖筛查计划中进行的口服葡萄糖耐量测试中，他显示出糖尿病模式和正常的胰岛素反应。他的总脂肪面积高达239.4 cm ² ；特别是，他的内脏脂肪面积为103.0cm ² ，内脏脂肪面积与皮下脂肪面积的比率很高（0.76）。本病例可能表明，胰岛素抵抗可能是小于胎龄儿2型糖尿病的发病机制，而胰岛素抵抗可能是由于大量内脏脂肪积累所致。

更新日期：2020-03-26

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