Efficient Reduction of Oxazolyl‐Bearing Secondary Anilides to Amines by Nickel‐Catalyzed Hydrosilylation,Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Efficient Reduction of Oxazolyl‐Bearing Secondary Anilides to Amines by Nickel‐Catalyzed Hydrosilylation
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-19 , DOI: 10.1002/ajoc.202000054
Jian Zhou ₁ , Xiaofan Bo ₁ , Li Wan ₁ , Zhong Xin _{1,

2}

Affiliation

A convenient procedure for the catalytic hydrosilylation of secondary anilides bearing an oxazolyl group has been developed. In the presence of inexpensive NiBr₂, the reduction of functionalized secondary amides with nontoxic and air‐stable TMDS proceeded smoothly to give the corresponding functionalized amines. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for several sensitive functional groups such as halo, ester and nitro groups.

中文翻译：

镍催化的氢化硅烷化将含恶唑基的仲酸酐有效还原为胺

已经开发了一种方便的方法，用于带有恶唑基的仲酸酐催化氢化硅烷化。在廉价的NiBr ₂存在下，用无毒且空气稳定的TMDS还原官能化仲酰胺可顺利进行，得到相应的官能化胺。该方法对减少多种类型的底物显示出广泛的适用性，并且对几种敏感的官能团如卤素，酯和硝基具有良好的相容性和优异的化学选择性。

更新日期：2020-03-19

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11