Frailty assessment in older patients with haematological malignancies is extremely beneficial in order to optimize treatment decisions and supportive interventions. A comprehensive geriatric assessment can provide a better understanding of the functional age than clinical judgement by evaluating several skills domains such as physical function, autonomy, comorbidities, nutrition, cognition, psychological status and social support. However, the use of a multidisciplinary geriatric assessment may fail to detect unsuspected vulnerability such as mild cognitive impairment among so‐called “clinically fit” patients. The objective of this paper is to update the current knowledge about predictive factors for toxicity and “frailty scoring” in older patients with haematological malignancies. The unsuspected major role of cognitive impairment and how to detect it will be emphasized.

中文翻译：

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老年血液系统恶性肿瘤患者的虚弱评分：轻度认知障碍的意外作用。

为了优化治疗决策和支持性干预措施，对老年血液系统恶性肿瘤患者进行虚弱评估非常有益。通过评估身体，自律，合并症，营养，认知，心理状况和社会支持等多个技能领域，全面的老年医学评估可以比临床判断更好地了解功能年龄。但是，使用多学科的老人评估方法可能无法检测出未曾怀疑的脆弱性，例如所谓的“临床适合”患者中的轻度认知障碍。本文的目的是更新有关血液系统恶性肿瘤老年患者毒性和“脆弱评分”的预测因素的最新知识。