当前位置: X-MOL 学术Eur. J. Org. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
CF3-Containing para-Quinone Methides for Organic Syntheses
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-30 , DOI: 10.1002/ejoc.202000295
Michael Winter 1 , Roman Schütz 1 , Andreas Eitzinger 1 , Armin R Ofial 2 , Mario Waser 1
Affiliation  

A new family of CF3‐containing para‐quinone methides (CF3‐QMs) was systematically investigated for its suitability in organic synthesis. Addition of different nucleophiles gives access to target molecules with a benzylic CF3‐containing stereogenic center straightforwardly. The electrophilicity parameter E of the prototypical CF3‐QM 2,6‐di‐tert‐butyl‐4‐(2,2,2‐trifluoroethylidene)cyclohexa‐2,5‐dien‐1‐one was determined to be –11.68 according to the Mayr scale, making it one of the most reactive quinone methides known so far.

中文翻译:


用于有机合成的含 CF3 对醌甲基化物



对一类新的含 CF3 对醌甲基化物 (CF3-QMs) 的有机合成适用性进行了系统研究。添加不同的亲核试剂可以直接获得具有含苄基 CF3 立体中心的目标分子。根据以下公式,原型 CF3-QM 2,6-二叔丁基-4-(2,2,2-三氟亚乙基)环六-2,5-二烯-1-酮的亲电性参数 E 为 –11.68迈尔标度,使其成为迄今为止已知的最具反应性的醌甲基化物之一。
更新日期:2020-03-30
down
wechat
bug