The synthesis and characterization of 3D mesoporous CeO2 hollow spheres as a modifier for the simultaneous determination of amlodipine, hydrochlorothiazide and valsartan,Analytical Methods

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The synthesis and characterization of 3D mesoporous CeO2 hollow spheres as a modifier for the simultaneous determination of amlodipine, hydrochlorothiazide and valsartan
Analytical Methods ( IF 2.7 ) Pub Date : 2020-03-06 , DOI: 10.1039/d0ay00022a
Najmeh Farvardin _{1,

2,

3,

4,

5} , Shohreh Jahani _{5,

6,

7} , Maryam Kazemipour _{1,

2,

3,

4,

5} , Mohammad Mehdi Foroughi _{1,

2,

3,

4,

5}

Affiliation

Herein, mesoporous CeO₂ hollow spheres (M-CeO₂-HSs) with a three-dimensional configuration were synthesized via a facile strategy. The morphology and structure of the three-dimensional M-CeO₂-HSs were characterized via XRD, SEM, and EDX. In order to demonstrate their practical application, the as-prepared M-CeO₂-HSs were applied as a modifier, which exhibited high catalytic activity for the simultaneous detection of amlodipine (AML), hydrochlorothiazide (HCTZ) and valsartan (VAL). Furthermore, a modified electrode was fabricated and investigated via electrochemical impedance spectroscopy (EIS). An unmodified GCE and the M-CeO₂-HS-modified glassy carbon electrode (M-CeO₂-HS/GCE) were utilized to assess their electrochemical behaviors towards AML, HCTZ and VAL. It was observed that the electrochemical responses of M-CeO₂-HS/GCE towards these analytes were remarkably enhanced. M-CeO₂-HS/GCE exhibited satisfactory responses for AML, HCTZ and VAL with detection limits of 7.9 nmol L⁻¹, 3.8 nmol L⁻¹ and 5.4 nmol L⁻¹ (S/N = 5), respectively. The diffusion coefficient (D) and heterogeneous rate constant (k_h) were detected for the oxidation of AML, HCTZ and VAL on the surface of the modified electrode. In addition, the analytical application of M-CeO₂-HS/GCE was investigated, which demonstrated acceptable results for the simultaneous detection of AML, HCTZ and VAL in real specimens.

中文翻译：

3D介孔CeO2空心球的合成及表征，用于同时测定氨氯地平，氢氯噻嗪和缬沙坦

在此，通过简便的策略合成了具有三维结构的介孔CeO ₂空心球（M-CeO ₂ -HSs）。通过XRD，SEM和EDX表征了三维M-CeO ₂ -HSs的形貌和结构。为了证明其实际应用，将所制备的M-CeO ₂ -HSs用作改性剂，对氨氯地平（AML），氢氯噻嗪（HCTZ）和缬沙坦（VAL）的同时检测具有高催化活性。此外，制造了一种修饰电极，并通过电化学阻抗谱（EIS）进行了研究。未经修改的GCE和M-CeO ₂-HS修饰的玻碳电极（M-CeO ₂ -HS / GCE）用于评估其对AML，HCTZ和VAL的电化学行为。观察到，M-CeO ₂ -HS / GCE对这些分析物的电化学反应显着增强。M-的CeO ₂ -HS / GCE展示的AML，HCTZ和VAL令人满意的回答与7.9纳摩尔L检测限^-1，3.8纳摩尔大号^-1和5.4纳摩尔大号^-1（S / N = 5），分别。检测了修饰电极表面上AML，HCTZ和VAL的氧化扩散系数（D）和非均相速率常数（k _h）。此外，M-CeO的分析应用_对2- HS / GCE进行了研究，结果证明了在同时检测真实标本中的AML，HCTZ和VAL时可以接受的结果。

更新日期：2020-04-24

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