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Effective SERS method for identification of dexmedetomidine hydrochloride in biological samples
Analytical Methods ( IF 2.7 ) Pub Date : 2020/03/06 , DOI: 10.1039/d0ay00019a Siqingaowa Han 1, 2, 3, 4, 5 , Chen Zhang 1, 2, 3, 4 , Xuanyu Sha 1, 2, 3, 4 , Nan Li 1, 2, 3, 4 , Wuliji Hasi 1, 2, 3, 4 , Yanhua Zhang 4, 6, 7
Analytical Methods ( IF 2.7 ) Pub Date : 2020/03/06 , DOI: 10.1039/d0ay00019a Siqingaowa Han 1, 2, 3, 4, 5 , Chen Zhang 1, 2, 3, 4 , Xuanyu Sha 1, 2, 3, 4 , Nan Li 1, 2, 3, 4 , Wuliji Hasi 1, 2, 3, 4 , Yanhua Zhang 4, 6, 7
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In recent years, the abuse of dexmedetomidine hydrochloride (DH) in various criminal cases has increased demand for the rapid and effective supervision and determination of DH. In this paper, based on the SERS method, DH in aqueous solution, urine and serum was effectively and sensitively detected. On the basis of density functional theory (DFT), the Raman peaks of DH were identified by systematic calculation. The SERS performance for the measurement of DH was compared between Ag colloid and paper-based substrate. It was found that Ag colloid together with KI as an aggregator was equipped with better SERS behavior and could thus be applied in the analysis of DH in biological samples. Furthermore, with simple pre-treatment, DH in urine and serum were successfully determined with detection limits down to 10 μg mL−1 and 12 μg mL−1, respectively. The linear relationships between the characteristic peak intensity and the concentration of DH in urine and serum were established and the recovery rates were calculated with low relative standard deviation (RSD). This fast, accurate and non-destructive SERS method lays a reliable foundation for rapid on-site detection of DH.
中文翻译：
有效的SERS方法鉴定生物样品中盐酸右美托咪定
近年来，在各种刑事案件中滥用盐酸右美托咪定（DH）的需求增加了对快速有效监测和确定DH的需求。本文基于SERS方法，可以有效，灵敏地检测水溶液，尿液和血清中的DH。根据密度泛函理论（DFT），通过系统计算确定了DH的拉曼峰。在Ag胶体和纸基基材之间比较了DH的SERS性能。发现Ag胶体与KI一起作为聚集体具有更好的SERS行为，因此可以用于生物样品中DH的分析。此外，通过简单的预处理，尿样和血清中的DH即可成功测定，检出限低至10μgmL -1和12μgmL -1。建立了特征峰强度与尿液和血清中DH浓度之间的线性关系，并以较低的相对标准偏差（RSD）计算了回收率。这种快速，准确且无损的SERS方法为快速现场检测DH奠定了可靠的基础。
更新日期：2020-03-27
中文翻译：
有效的SERS方法鉴定生物样品中盐酸右美托咪定
近年来，在各种刑事案件中滥用盐酸右美托咪定（DH）的需求增加了对快速有效监测和确定DH的需求。本文基于SERS方法，可以有效，灵敏地检测水溶液，尿液和血清中的DH。根据密度泛函理论（DFT），通过系统计算确定了DH的拉曼峰。在Ag胶体和纸基基材之间比较了DH的SERS性能。发现Ag胶体与KI一起作为聚集体具有更好的SERS行为，因此可以用于生物样品中DH的分析。此外，通过简单的预处理，尿样和血清中的DH即可成功测定，检出限低至10μgmL -1和12μgmL -1。建立了特征峰强度与尿液和血清中DH浓度之间的线性关系，并以较低的相对标准偏差（RSD）计算了回收率。这种快速，准确且无损的SERS方法为快速现场检测DH奠定了可靠的基础。
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