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Metal free amination of congested and functionalized alkyl bromides at room temperature.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-04-30 , DOI: 10.1039/d0cc00826e
Arshad J Ansari 1 , Ayushi Yadav , Anirban Mukherjee , Elagandhula Sathish , Kommu Nagesh , Ritesh Singh
Affiliation  

Herein, we report a highly facile and unprecedented approach to synthesize congested N-(hetero)aryl amines en route to α-amino acid amides using α-bromoamides as alkylating agents under mild reaction conditions (room temperature). The involvement of aza-oxyallyl cations as alkylating agents is the hallmark of this reaction. The method was readily adapted for the rapid synthesis of coveted 1,4-benzodiazepine-3,5-diones.

中文翻译:

室温下,经过充填和官能化的烷基溴的无金属胺化反应。

在本文中,我们报道了在温和的反应条件(室温)下,使用α-溴酰胺作为烷基化剂,在α-氨基酸酰胺的途中合成拥挤的N-(杂)芳基胺的一种高度简便且前所未有的方法。氮杂-氧基烯丙基阳离子作为烷基化剂的参与是该反应的标志。该方法很容易用于梦synthesis以求的1,4-苯二氮杂3,5-二酮的快速合成。
更新日期:2020-03-06
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