During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.

2014年4月至6月，在秘鲁伊基托斯市附近的疟疾流行农村社区，我们检测到14名高热人群感染了瓜罗阿病毒（GROV）的证据，其中6人也存在间日疟原虫疟疾的证据。通过长期的发热疾病监测网络在当地参与的医疗机构中发现了病例。通过结合血清转化和病毒分离鉴定出GROV病例，并通过浓涂和PCR确诊了疟疾。GROV单一感染表现为非特异性发热性疾病，在临床上与GROV和间日疟原虫没有区别合并感染。这一系列病例突出显示了在秘鲁农村的亚马逊地区，特别是在疟疾流行地区，GROV传播的可能性。对亚马逊河类似地区的进一步研究可能提供洞察亚马逊盆地GROV传播的程度。