Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan,Emerging Infectious Diseases

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Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan
Emerging Infectious Diseases ( IF 7.2 ) Pub Date : 2020-03-05 , DOI: 10.3201/eid2604.190840
Chi-Jung Wu , Wei-Lun Liu , Chih-Cheng Lai , Chien-Ming Chao , Wen-Chien Ko , Hsuan-Chen Wang , Ching-Tzu Dai , Ming-I Hsieh , Pui-Ching Choi , Jia-Ling Yang , Yee-Chun Chen

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR₃₄/L98H, TR₃₄/L98H/S297T/F495I, and TR₄₆/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

更新日期：2020-03-16

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