Shigellosis outbreaks caused by Shigella with decreased susceptibility to azithromycin (DSA-Shigella) among men who have sex with men (MSM) have been reported worldwide. We describe sexual health indicators and antimicrobial drug resistance for shigellosis cases in Minnesota, USA. We analyzed a sample of isolates received during 2012–2015 and cross-referenced cases with the Minnesota Department of Health Sexually Transmitted Disease Database to ascertain patients’ HIV status and recent chlamydia, gonorrhea, and syphilis infections. Of 691 Shigella isolates, 46 (7%) were DSA-Shigella; 91% of DSA-Shigella patients were men, of whom 60% were living with HIV. Among men, those with DSA-Shigella infection had greater odds of living with HIV, identifying as MSM, or having a recent diagnosis of a sexually transmitted disease. DSA-Shigella was associated with MSM, HIV infection, and recent sexually transmitted disease. To decrease spread of DSA-Shigella, interventions targeted at communities at high risk are needed.

世界范围内已报道了由志贺氏菌引起的志贺氏菌病暴发，对与阿奇霉素（DSM- Shigella）的男性易感性下降。我们描述了在美国明尼苏达州志贺菌病病例的性健康指标和抗菌药物耐药性。我们对明尼苏达州卫生部性传播疾病数据库中2012年至2015年期间收到的分离株样本和交叉参考病例进行了分析，以确定患者的HIV状况以及最近的衣原体，淋病和梅毒感染情况。在691株志贺氏菌中，DSA-志贺氏菌占46（7％）。DSA-志贺氏菌患者中有91％是男性，其中60％患有HIV。在男性中，患有DSA-志贺氏菌的人感染者更容易感染HIV，被确认为MSM或最近被诊断出性传播疾病。DSA-志贺氏菌与MSM，HIV感染和最近的性传播疾病有关。为了减少DSA-志贺氏菌的传播，需要针对高危社区的干预措施。