Abstract

Pure zinc oxide NPs (ZnO NPs) have been synthesized using a simple eco-friendly approach using fruit extracts of Hyphaene thebaica. XRD pattern indicated zincite and highly crystalline phase of ZnO NPs. UV–Vis spectrum revealed surface plasmon resonance at 372 nm and bandgap of 3.36 eV. FTIR spectrum indicated characteristic Zn–O vibration at 450 cm⁻¹. HRTEM images indicated particle size in the range of 8–23 nm having a quasi spherical morphology. Raman shift was observed at 297 cm⁻¹, 405 cm⁻¹ and 548 cm⁻¹. Excellent protein kinase (PK) inhibition and varying antimicrobial potential against different bacterial and fungal strains is reported. E. coli and A. flavus were found as the most susceptible microbial strains. Hemocompatability of the ZnO NPs was revealed. ZnO NPs indicated a dose dependant cytotoxicity. MTT assay revealed a median lethal concentration (IC₅₀) of 106 µg/mL against Leishmania tropica. Different antioxidant assays indicated the antioxidant potential of ZnO NPs. Hyphaene thebaica mediated ZnO NPs revealed excellent therapeutic performance and can used as a potential candidate for diverse biomedical applications.

Graphic Abstract

中文翻译：

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使用Hyphaene thebaica（L.）Mart的ZnO纳米颗粒的结构，形态和生物学特征。水果

摘要

使用Hyphaene thebaica的果实提取物，采用一种简单的生态友好方法合成了纯氧化锌NP（ZnO NP）。XRD图谱表明锌矿和ZnO NPs的高度结晶相。UV-Vis光谱显示表面等离振子共振在372 nm和带隙为3.36 eV。FTIR光谱显示Zn-O在450 cm ^-1处的振动特征。HRTEM图像表明颗粒大小在8-23 nm之间，具有准球形形态。在297厘米观察到的拉曼位移^-1，405厘米^-1和548厘米^-1。据报道，其对不同细菌和真菌菌株具有出色的蛋白激酶（PK）抑制作用和不同的抗菌潜力。大肠杆菌和黄曲霉被发现是最易感染的微生物菌株。揭示了ZnO NPs的血液相容性。ZnO NPs表现出剂量依赖性的细胞毒性。MTT分析显示，对热带利什曼原虫的致死性浓度中位数（IC ₅₀）为106 µg / mL 。不同的抗氧化剂测定表明ZnO NP的抗氧化潜力。Hyphaene thebaica介导的ZnO NPs表现出优异的治疗性能，可作为多种生物医学应用的潜在候选者。

图形摘要