Glycolysis is the core of intermediate metabolism, an ancient pathway discovered in the heydays of classic biochemistry. A hundred years later, it remains a matter of active research, clinical interest and is not devoid of controversy. This review examines topical aspects of glycolysis in the brain, a tissue characterized by an extreme dependence on glucose. The limits of glycolysis are reviewed in terms of flux control by glucose transporters, intercellular lactate shuttling and activity-dependent glycolysis in astrocytes and neurons. What is the site of glycogen mobilization and aerobic glycolysis in brain tissue? We scrutinize the pervasive notions that glycolysis is fast and that catalysis is channeled through supramolecular assemblies. In brain tissue, most glycolytic enzymes are catalytically silent. What then is their function?

中文翻译：

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流脑糖酵解：极限，速度，位置，月光以及糖原和乳酸的命运。

糖酵解是中间代谢的核心，这是在经典生物化学鼎盛时期发现的古老途径。一百年后，它仍然是一个活跃的研究和临床兴趣的问题，并且没有争议。这项审查审查了大脑中糖酵解的局部方面，该组织的特征是对葡萄糖的极端依赖。糖酵解的极限在通过葡萄糖转运蛋白的通量控制，星形胶质细胞和神经元中的细胞间乳酸穿梭和活性依赖性糖酵解方面进行了综述。脑组织中糖原动员和有氧糖酵解的位点是什么？我们仔细研究了普遍存在的观念，即糖酵解速度很快，而催化作用是通过超分子组装来进行的。在脑组织中，大多数糖酵解酶催化沉默。它们的功能是什么？