Objectives

To clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA) through a 5-year follow-up.

Methods

Overall, 472 participants and 944 knees were eligible. MME (mm) was measured at the baseline, and KOA was radiographically evaluated at both baseline and 5-year follow-up by Kellgren-Lawrence grade (KLG). Radiographic KOA (ROA) was defined as the knee showing KLG ≥ 2. Incident ROA (iROA) was defined if the baseline KLG of 0–1 increased to KLG ≥ 2 in 5 years. Progressive ROA (pROA) was defined if the baseline KLG of 2–3 worsened to a higher grade in 5 years. Receiver operating characteristic (ROC) curve and generalized estimating equations were used for analysis.

Results

Of 574 non-ROA knees at the baseline, 43 knees (7.5%) developed iROA; of 370 ROA knees, 47 knees (12.7%) developed pROA. Based on the ROC curves, 4 mm was the optimal cutoff to detect the risk of iROA (area under curve [AUC] 0.639 [right knee]; AUC 0.641 [left knee]) and that of pROA (AUC 0.750 [right knee]; AUC 0.863 [left knee]). Multiple regression analysis showed that the 4-mm cutoff of MME was significantly associated with both the prevalence of iROA (regression coefficient [B] 1.909; p ≤ 0.001; adjusted odds ratio [aOR] 6.746) and that of pROA (B 1.791; p ≤ 0.001; aOR 5.993).

Conclusions

On ultrasonography, the participants with more extruded medial meniscus showed a higher prevalence of both iROA and pROA. Ultrasonography could identify patients who had a risk of developing KOA.

Key Points

• Through a 5-year follow-up, the current cohort study was conducted to clarify the relationship between the baseline value of medial meniscus extrusion (MME) and the radiographic change of knee osteoarthritis (KOA).

• More extruded medial meniscus evaluated by ultrasonography was associated with the development of radiographic KOA.

• Ultrasonography could identify the patients who had a risk of developing KOA, and the 4-mm cutoff of MME was optimal to detect this risk.

中文翻译：

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美国对内侧半月板挤压的检测可以预测发生放射照相的膝部骨关节炎的风险：一项为期5年的队列研究。

目标

通过5年的随访，以阐明内侧半月板挤压（MME）的基线值与膝部骨关节炎（KOA）的放射学改变之间的关系。

方法

总体上，有472名参与者和944膝参加了比赛。在基线测量MME（毫米），并在基线和5年随访中通过Kellgren-Lawrence评分（KLG）进行X线照相评估KOA。放射线KOA（ROA）定义为显示KLG≥2的膝盖。如果5年内基线KLG从0–1增加到KLG≥2，则定义事件ROA（iROA）。如果基线KLG 2–3在5年内恶化到较高等级，则定义为进行性ROA（pROA）。使用接收器工作特性（ROC）曲线和广义估计方程进行分析。

结果

在基线的574个非ROA膝盖中，有43个膝盖（7.5％）发展为iROA。在370个ROA膝盖中，有47个膝盖（12.7％）出现了pROA。根据ROC曲线，4 mm是检测iROA（曲线下面积[AUC] 0.639 [右膝]； AUC 0.641 [左膝]）和pROA（AUC 0.750 [右膝]）的风险的最佳临界值。 AUC 0.863 [左膝]）。多元回归分析表明，MME的4毫米截止值显著与两个相关联IROA的患病率（回归系数[乙] 1.909; p  ≤0.001;调整比值比[aOR为] 6.746），并且菌ProA（的乙1.791; p  ≤0.001； aOR 5.993）。

结论

在超声检查中，内侧半月板突出的参与者显示iROA和pROA的患病率较高。超声检查可以识别出有发生KOA风险的患者。

关键点

•通过5年的随访，进行了当前的队列研究，以阐明内侧半月板挤压（MME）的基线值与膝骨关节炎（KOA）的影像学改变之间的关系。

•通过超声检查评估出的半月板内侧半月板增多与放射线KOA的发展有关。

•超声检查可以识别出有发生KOA风险的患者，并且MME的4 mm临界值是检测该风险的最佳选择。