Trace amines have been reported to be neuromodulators of monoaminergic systems. Trace amines receptor 5 (TAAR5) is expressed in several regions of mice central nervous system, such as amygdala, arcuate nucleus and ventromedial hypothalamus, but very limited information is available on its functional role. The purpose of this study is to examine the effect of TAAR5 agonist alpha-NETA on the generation of mismatch negativity (MMN) analogue in C57BL/6 mice. Event-related potentials have been recorded from awake mice in oddball paradigms before and after the alpha-NETA administration. Alpha-NETA has been found to decrease N40 MMN-like difference, which resulted from the increased response to standard stimuli. An opposite effect has been found for the P80 component: the amplitude increased in response both to standard and deviant stimuli. A significant increase in N40 peak latency after the alpha-NETA administration has been found. This may suggest a reduced speed of information processing similar to the increase in P50 and N100 components latencies in schizophrenia patients. These results provide new evidence for a role of TAAR5 in cognitive processes.

据报道，微量胺是单胺能系统的神经调节剂。微量胺受体 5 (TAAR5) 在小鼠中枢神经系统的几个区域表达，如杏仁核、弓状核和下丘脑腹内侧，但关于其功能作用的信息非常有限。本研究的目的是检查 TAAR5 激动剂 alpha-NETA 对 C57BL/6 小鼠错配阴性 (MMN) 类似物产生的影响。在 alpha-NETA 给药之前和之后，在古怪范式中从清醒小鼠中记录了与事件相关的电位。已发现 Alpha-NETA 可减少 N40 MMN 样差异，这是由于对标准刺激的反应增加所致。已发现 P80 分量具有相反的效果：响应标准和异常刺激，振幅均增加。发现 alpha-NETA 给药后 N40 峰值延迟显着增加。这可能表明信息处理速度降低，类似于精神分裂症患者 P50 和 N100 成分延迟的增加。这些结果为 TAAR5 在认知过程中的作用提供了新的证据。