The data of transmission electron microscopy (TEM) on morphology of M. tuberculosis H37Rv bacterial cells treated with four analogues of pyrimidine nucleosides with different substituents at 5 position of base are presented. We showed that the growth of M. tuberculosis H37Rv cells effectively inhibited by each of these compounds. This process is accompanied with the accumulation of lipid intracellular vacuole-like inclusions in the cells, appearance of deep protrusions and indentations on the surface, partial and/or complete destruction of the three-layered cell envelope. The exact molecular mechanism of action of 5-substituted pyrimidine nucleosides on M. tuberculosis cells remains to be proved. However, one can suggest that mechanism of action for these compounds is related either to their direct interactions with bacteria cell walls or to interactions with enzymes participating in the process of cell wall formation.

呈现了用四个嘧啶核苷类似物在碱基的5位上具有不同取代基处理的结核分枝杆菌H37Rv细菌细胞的形态的透射电子显微镜（TEM）数据。我们表明，结核分枝杆菌H37Rv细胞的生长被这些化合物有效抑制。该过程伴随细胞中脂质细胞内液泡状内含物的积累，表面上深突起和凹痕的出现，三层细胞包膜的部分和/或完全破坏。5-取代的嘧啶核苷对结核分枝杆菌细胞起作用的确切分子机制仍有待证明。然而，