A series of copolymers [P (TMC-co-DTC)] with different molecular weights based on trimethylene carbonate (TMC) and 2, 2′-dimethyltrimethylene carbonate (DTC) were synthesized via ring-opening copolymerization, by adjusting the amount of Sn(Oct)₂. The thermal performance showed that the T_g and T_d of the obtained amorphous copolymer rose with the increase of molecular weight from 118 to 213 kDa. Then the in vitro enzymatic experiment was carried out in lipase solutions, it could be concluded that the higher the molecular weight, the faster the degradation rate of the P (TMC-co-DTC), which may be related to the stronger hydrophobicity of the high molecular weight sample. Furthermore, the degradation mechanism of P (TMC-co-DTC) was determined to be the surface erosion, due to the result of the unchanged molecular weight during the degradation period. The fact that polycarbonate copolymer produces no acidic compounds in the process of enzymatic degradation had also been confirmed. This study provides confirmation for adjusting the degradation behavior performance of polycarbonate materials by molecular weight to meet the needs of more abundant clinical applications.

通过开环共聚，通过调节Sn的量，合成了一系列基于碳酸三亚甲基酯（TMC）和2，2'-二甲基碳酸三亚甲基酯（DTC）的不同分子量的共聚物[P（TMC-co-DTC）]。 （十月）₂。热性能表明，所得无定形共聚物的T _g和T _d随着分子量从118kDa增加至213kDa而升高。然后是体外在脂肪酶溶液中进行了酶促实验，可以得出结论，分子量越高，P（TMC-co-DTC）的降解速度越快，这可能与高分子量样品的较强疏水性有关。 。此外，由于降解期间分子量不变的结果，P的降解机理被确定为表面腐蚀。也已经证实了聚碳酸酯共聚物在酶促降解过程中不产生酸性化合物的事实。这项研究为通过分子量调节聚碳酸酯材料的降解行为性能以满足更丰富的临床应用需求提供了确认。