Background

The effectiveness of SMS reminders in improving vaccination coverage has been assessed previously, with effectiveness varying between settings. However, there are very few studies on their effect on the timeliness of vaccination.

Design

Unblinded, randomised controlled trial with blocked sampling.

Methods

1594 Australian infants and young children were recruited to assess the impact of (1) SMS reminders only, (2) a personalised calendar, (3) SMS reminder and personalised calendar and (4) no intervention, on receipt of vaccine within 30 days of the due date. Outcomes were measured for receipt of vaccines due at 2, 4, 6, 12 and 18 months of age. A post-hoc assessment was also conducted of the impact of a new national “No jab No Pay” policy introduced during the trial, which removed philosophical objections as an exemption for financial penalties for non-vaccination.

Results

There was a statistically significant improvement in on-time vaccination only at the 12 month schedule point amongst infants who received SMS reminders alone (RR 1.09, 95% CI 1.01–1.18) or in combination with a personalised calendar (1.11, CI 1.03–1.20) compared to controls. This impact was limited to participants who had received one or more previous doses late. No statistically significant impacts of calendar interventions alone were seen. There was a high rate of on-time compliance amongst control participants − 95%, 86%, 80%, 74% at the 4, 6, 12 and 18 month schedule points respectively, which increased more than 10 percentage points after implementation of the “No Jab, No Pay” policy.

Conclusions

SMS reminders are more effective in improving timeliness where pre-existing compliance is lower, but the 18 month schedule point appeared to be less amenable to intervention. Australia and New Zealand Clinical Trial Registration No. ACTRN12614000970640.

中文翻译：

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SMS消息和日历提醒的随机对照试验，可改善婴儿的疫苗接种及时性。

背景

之前已经评估了SMS提醒在改善疫苗接种范围方面的有效性，不同设置的有效性有所不同。但是，关于它们对疫苗及时性的影响的研究很少。

设计

随机抽样的无盲随机对照试验。

方法

招募了1594名澳大利亚婴幼儿来评估（1）仅在SMS提醒，（2）个性化日历，（3）SMS提醒和个性化日历以及（4）在干预后30天内接种疫苗后的影响。截止日期。测量在2、4、6、12和18个月大时应接种疫苗的结果。还对审判期间引入的一项新的国家“无刺杀无薪”政策的影响进行了事后评估，该政策取消了哲学上的反对意见，以免除未接种疫苗的经济处罚。

结果

仅在收到SMS提示（RR 1.09，95％CI 1.01-1.18）或与个性化日历结合使用（1.11，CI 1.03-1.20）的婴儿中，仅在12个月的时间表上，按时接种疫苗的统计学意义上的显着改善）与对照相比。这种影响仅限于迟到一剂或多剂的参与者。没有单独的日历干预措施有统计上的显着影响。对照参与者的准时达标率很高-在4、6、12和18个月的时间表点分别达到95％，86％，80％，74％，自从实施该规则后，该比例提高了10个百分点以上“无戳，无酬”政策。

结论

SMS提醒在改善先前合规性较低的及时性方面更有效，但是18个月的时间表似乎不太适合干预。澳大利亚和新西兰临床试验注册号：ACTRN12614000970640。