Circular RNAs (circRNAs) are widely expressed in eukaryotic cells and play a key role in atherosclerosis. The aim of this study is to explore the relationship between hsa_circ_0003204 and atherosclerosis. Here, hsa_circ_0003204 was aberrantly overexpressed in the ox-LDL-induced human umbilical vein endothelial cells (HUVECs). Knockdown of hsa_circ_0003204 facilitated the proliferation, migration, and invasion but reduced the apoptosis of oxLDL-induced HUVECs. Furthermore, hsa_circ_0003204 knockdown significantly reduced the E-cadherin expression but increased the expressions of N-cadherin and vimentin in oxLDL-induced HUVECs. Collectively, these findings suggest that hsa_circ_0003204 plays an important role in the proliferation and angiogenesis of HUVECs, providing a potential target for treating endothelial cell damage in atherosclerosis.

环状RNA（circRNA）在真核细胞中广泛表达，在动脉粥样硬化中起关键作用。本研究旨在探讨 hsa_circ_0003204 与动脉粥样硬化之间的关系。在这里，hsa_circ_0003204 在 ox-LDL 诱导的人脐静脉内皮细胞 (HUVEC) 中异常过度表达。hsa_circ_0003204 的敲低促进了增殖、迁移和侵袭，但减少了 oxLDL 诱导的 HUVEC 的凋亡。此外，hsa_circ_0003204 敲低显着降低了 oxLDL 诱导的 HUVEC 中 E-钙粘蛋白的表达，但增加了 N-钙粘蛋白和波形蛋白的表达。总的来说，这些发现表明 hsa_circ_0003204 在 HUVEC 的增殖和血管生成中起重要作用，为治疗动脉粥样硬化中的内皮细胞损伤提供了潜在的靶点。