Calcium carbonate nanoparticles (CaCO3NPs) derived from CO2 are promising materials for different industrial applications. It is imperative to understand their toxicological profile in biological systems as the human and environmental exposures to CaCO3NPs increases with growing production. Here, we analyse the cytotoxicity of CaCO3NPs synthesized from a CaO slurry on two cell lines, and in vivo on zebrafish (Danio Rerio). Our results demonstrate the CaCO3NPs in vitro safety as they do not cause cell death or genotoxicity. Moreover, zebrafish treated with CaCO3NPs develop without any abnormalities, confirming the safety and biocompatibility of this nanomaterial.

中文翻译：

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工业应用碳酸钙纳米颗粒的毒理学概况。

源自二氧化碳的碳酸钙纳米粒子（CaCO3NPs）是用于不同工业应用的有前途的材料。必须了解它们在生物系统中的毒理学特征，因为随着产量的增长，人类和环境对CaCO3NPs的暴露量会增加。在这里，我们分析了由CaO浆液在两种细胞系上合成的CaCO3NPs的细胞毒性，以及在斑马鱼体内（Danio Rerio）的体内毒性。我们的结果证明了CaCO3NPs不会引起细胞死亡或遗传毒性，因此具有体外安全性。此外，用CaCO3NPs处理的斑马鱼无任何异常发育，证实了这种纳米材料的安全性和生物相容性。