Metabolism, is a transversal hot research topic in different areas, resulting in the integration of cellular needs with external cues, involving a highly coordinated set of activities in which nutrients are converted into building blocks for macromolecules, energy currencies and biomass. Importantly, cells can adjust different metabolic pathways defining its cellular identity. Both cancer cell and embryonic stem cells share the common hallmark of high proliferative ability but while the first represent a huge social-economic burden the second symbolize a huge promise. Importantly, research on both fields points out that stem cells share common metabolic strategies with cancer cells to maintain their identity as well as proliferative capability and, vice versa cancer cells also share common strategies regarding pluripotent markers. Moreover, the Warburg effect can be found in highly proliferative non-cancer stem cells as well as in embryonic stem cells that are primed towards differentiation, while a bivalent metabolism is characteristic of embryonic stem cells that are in a true naïve pluripotent state and cancer stem cells can also range from glycolysis to oxidative phosphorylation. Therefore, this review aims to highlight major metabolic similarities between cancer cells and embryonic stem cells demonstrating that they have similar strategies in both signaling pathways regulation as well as metabolic profiles while focusing on key metabolites.

中文翻译：

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茎部新陈代谢：来自代谢代谢的见解，反之亦然。

代谢是不同领域的一个横向研究热点，它导致细胞需求与外部线索的整合，涉及一系列高度协调的活动，其中营养物质被转化为大分子，能量货币和生物质的基础。重要的是，细胞可以调节定义其细胞身份的不同代谢途径。癌细胞和胚胎干细胞都具有高增殖能力的共同特征，但第一个代表巨大的社会经济负担，第二个象征着巨大的希望。重要的是，在这两个领域的研究均指出，干细胞与癌细胞具有共同的代谢策略，以维持其身份以及增殖能力，反之亦然，癌细胞也具有与多能标记物相同的通用策略。此外，Warburg效应可在高度增殖的非癌干细胞以及启动分化的胚胎干细胞中发现，而二价代谢是处于真正幼稚多能状态的胚胎干细胞的特征，而癌症干细胞可以也包括糖酵解到氧化磷酸化。因此，本综述旨在突出癌细胞和胚胎干细胞之间的主要代谢相似性，表明它们在关注关键代谢物的同时，在信号传导途径调控和代谢概况方面也具有相似的策略。尽管二价代谢是处于真正幼稚多能状态的胚胎干细胞的特征，并且癌症干细胞的范围也从糖酵解到氧化磷酸化。因此，本综述旨在突出癌细胞和胚胎干细胞之间的主要代谢相似性，表明它们在关注关键代谢物的同时，在信号传导途径调控和代谢概况方面也具有相似的策略。尽管二价代谢是处于真正幼稚多能状态的胚胎干细胞的特征，并且癌症干细胞的范围也从糖酵解到氧化磷酸化。因此，本综述旨在突出癌细胞和胚胎干细胞之间的主要代谢相似性，表明它们在关注关键代谢物的同时，在信号传导途径调控和代谢概况方面也具有相似的策略。