OBJECTIVE Although cisplatin (CIS) acts as potent chemotherapy, nephrotoxicity still its major life-threatening side effect. The purpose of this study was to discuss and compare the renoprotective effects of curcumin (CUR) and etoricoxib (ETB) against CIS-induced nephrotoxicity. MATERIALS & METHODS Thirty six adult female rats were divided equally into 6 groups: Group I (control), Group II (CIS) received cisplatin (7.5 mg/kg i.p), Group III (CUR) and group IV (ETB) received curcumin (200 mg/kg/day) or etoricoxib (10 mg/kg/day) respectively via gavage for seven continuous days. Group V (CIS + CUR) and Group VI (CIS + ETB) received curcumin (200 mg/kg/day) or etoricoxib (10 mg/kg/day) via gavage for seven continuous days. On the 4th day, the rats received cisplatin (7.5 mg/kg i.p) as a single injection 1 h after last curcumin or etoricoxib administration. At the assigned time, blood and tissue samples were collected for biochemical, histochemical, histopathological, immunohistochemical, and RT-PCR gene expression studies. RESULTS Curcumin administration significantly decreased CIS-induced elevation of serum creatinine and blood urea nitrogen (BUN), and reversed oxidative stress markers; glutathione (GSH) and malondialdehyde (MDA) to control level. Suppression of inflammatory and apoptotic responses by CUR co-treatment was evidenced by decreased iNOS and BAX immunohistochemical reactions, and TNF-α and Caspase3 gene expressions which were detected by RT-PCR in kidney tissues. To our knowledge, this is the first time to discuss the effect of ETB on CIS induced nephrotoxicity. Although ETB reduced the previously mentioned inflammatory and apoptotic markers, its effect was less than that of CUR. Administration of ETB couldn't modify the disturbed levels of creatinine, BUN, GSH, and MDA. CONCLUSION In conclusion, CUR provided a promising renoprotective effect against CIS induced nephrotoxicity. Further studies are recommended to approve or disapprove the protective role of ETB in CIS induced nephrotoxicity.

中文翻译：

---

姜黄素和依托考昔对顺铂诱发的大鼠急性肾损伤的比较肾保护作用。

目的尽管顺铂（CIS）可作为有效的化学疗法，但肾毒性仍是其威胁生命的主要副作用。这项研究的目的是讨论和比较姜黄素（CUR）和依托昔布（ETB）对CIS诱导的肾毒性的肾脏保护作用。材料与方法将36只成年雌性大鼠平均分为6组：第一组（对照组），第二组（CIS）接受顺铂（7.5 mg / kg腹腔注射），第三组（CUR）和第四组（ETB）接受姜黄素（ 200毫克/千克/天）或依托考昔（10毫克/千克/天）分别通过管饲法连续7天。V组（CIS + CUR）和VI组（CIS + ETB）连续七天接受姜黄素（200 mg / kg /天）或依托考昔（10 mg / kg /天）。在第4天，大鼠接受顺铂（7.5mg / kg i。p）在最后一次姜黄素或依托昔布给药后1小时以单次注射的形式给药。在指定的时间，收集血液和组织样本用于生化，组织化学，组织病理学，免疫组织化学和RT-PCR基因表达研究。结果姜黄素给药可显着降低CIS诱导的血清肌酐和血尿素氮（BUN）升高，并逆转氧化应激标志物；谷胱甘肽（GSH）和丙二醛（MDA）达到控制水平。肾组织中iNOS和BAX免疫组化反应的降低以及RT-PCR检测到的TNF-α和Caspase3基因的表达证明了CUR协同治疗抑制了炎症和凋亡反应。据我们所知，这是第一次讨论ETB对CIS诱导的肾毒性的作用。尽管ETB减少了前面提到的炎性和凋亡标记，但其作用不如CUR。ETB的管理不能改变肌酐，BUN，GSH和MDA的干扰水平。结论总之，CUR对CIS诱导的肾毒性提供了有希望的肾脏保护作用。建议进一步研究批准或不批准ETB在CIS诱导的肾毒性中的保护作用。