A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1, aldehydes 2, amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5-disubstituted thiazoles 6 in good yields as well.

中文翻译：

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从无味的异氰基（三苯基膦基亚芳基）乙酸酯开始，通过级联Ugi / Wittig环化反应，一锅四组分合成多取代的噻唑

通过级联的Ugi / Wittig环化反应，开发了一种新的单锅四组分多取代噻唑制剂。在三乙胺的存在下，无味的异氰基（三苯基正膦亚基）乙酸酯1，醛2，胺3和硫代羧酸4的四组分反应以中等至良好的产率产生了2,4,5-三取代的噻唑5。异（三苯基亚正膦）之间的双组分反应乙酸盐1个硫代羧酸4在三乙胺的存在提供了相应的4,5 -二取代的噻唑6以良好的收率，以及。