BACKGROUND Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. METHODS We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed from 2004 to 2016. Fifteen of 93 (16%) patients experienced a recurrence of TGA. RESULTS Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16.7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs. 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. CONCLUSIONS DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.

中文翻译：

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决定暂时性全球性失忆症复发的因素。

背景技术尽管已经提出了许多建议，包括短暂性全局性健忘症（TGA）的病因，包括缺血性，偏头痛或癫痫性病理。方法我们试图确定TGA的危险因素以及可能导致复发的预后因素。我们评估了93名潜在TGA患者的临床病史，家族史和磁共振弥散加权成像（DWI）研究。从2004年至2016年对患者进行随访。93例患者中有15例（16％）经历了TGA复发。结果在突发事件中，诱发Valsalva样动作的体育活动最为常见，其次是情绪压力。尽管没有单一的危险因素普遍存在，但84名患者可能存在TGA合并症或危险因素。与复发相关的危险因素是头部受伤（隔离vs. 复发，16.7％vs. 53.5％，p <0.01），抑郁症（孤立与复发，15.4％vs 46.7％，p = 0.01）和痴呆家族史（孤立与复发，20.5％vs. 46.7％，p = 0.03）。在确诊为复发性TGA的15例患者中，有2例发展为痴呆和4例主观记忆障碍。DWI病变在24例患者中观察到，位于海马内的任何位置。结论DWI病变与结局（复发，主观记忆障碍，痴呆）无显着相关性。我们发现抑郁症，先前的头部受伤和痴呆家族史可以预测TGA复发。两个发达的痴呆症和四个主观记忆障碍。DWI病变在24例患者中观察到，位于海马内的任何位置。结论DWI病变与结局（复发，主观记忆障碍，痴呆）无显着相关性。我们发现抑郁症，先前的头部受伤和痴呆家族史可以预测TGA复发。两个发达的痴呆症和四个主观记忆障碍。DWI病变在24例患者中观察到，位于海马内的任何位置。结论DWI病变与结局（复发，主观记忆障碍，痴呆）无显着相关性。我们发现抑郁症，先前的头部受伤和痴呆家族史可以预测TGA复发。