Fabrication of Tip-Hollow and Tip-Dissolvable Microneedle Arrays for Transdermal Drug Delivery,ACS Biomaterials Science & Engineering

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Fabrication of Tip-Hollow and Tip-Dissolvable Microneedle Arrays for Transdermal Drug Delivery
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-03-06 , DOI: 10.1021/acsbiomaterials.0c00120
Rui Ye ₁ , Jingbo Yang ₁ , Yanjun Li ₁ , Ying Zheng ₁ , Jian Yang ₁ , Yuanyuan Li ₁ , Bin Liu ₁ , Lelun Jiang ₁

Affiliation

We developed a modified micromolding method for the mass production of a novel tip-hollow microneedle array (MA). The tip-hollow MA was fabricated by tuning of the vacuum degree at −80 kPa for 60 s during the micromolding process. Subsequently, a tip-dissolvable MA encapsulated with drugs in the microcraters was fabricated from tip-hollow MA using repeated dipping and the freeze-drying process. Both the tip-hollow and tip-dissolvable MAs could easily penetrate in the rabbit skin without breakage, while the tip-hollow MA can just create a shallow loop hole in the skin. The drug-loaded tip-dissolvable MA can rapidly dissolve, releasing and diffusing the drug in the skin. The tip-dissolvable MA exhibited the best drug permeation ability in that the corresponding flux through the punctured skin using tip-dissolvable MA loaded with Rhodamine B is about 1.7- and 5.8-fold of that through the punctured skin using solid MA and the intact skin, respectively. The tip-dissolvable MA loaded with 5 IU insulin was fabricated to in vivo treat the type 1 diabetic SD rats. The tip-dissolvable MA had a good hypoglycemic effect and exhibited longer normoglycemic period in comparison with subcutaneous injection (5 IU). Therefore, our tip-dissolve MA is a promising medical device for transdermal drug delivery.

中文翻译：

尖端和可溶解的尖端的微针阵列的透皮药物输送的制作。

我们开发了一种改进的微成型方法，用于大规模生产新型中空微针阵列（MA）。通过在微成型过程中将真空度在-80 kPa下调节60 s来制造尖端空心MA。随后，使用重复浸入和冷冻干燥工艺，由尖端空心MA制成微囊中药物包裹的尖端可溶解MA。尖端中空和可溶解尖端的MA都可以轻松穿透兔子的皮肤而不会破裂，而尖端中空的MA只会在皮肤上形成一个浅环孔。载有药物的针尖可溶解的MA可以迅速溶解，释放和扩散皮肤中的药物。针尖可溶解的MA表现出最佳的药物渗透能力，因为使用装有若丹明B的针尖可溶解的MA的穿刺皮肤的相应通量约为使用固体MA和完整皮肤的穿刺皮肤的通量的1.7倍和5.8倍，分别。制备装有5 IU胰岛素的可溶于针尖的MA在体内治疗1型糖尿病SD大鼠。与皮下注射（5 IU）相比，可溶于针尖的MA具有良好的降血糖作用，并具有更长的降血糖期。因此，我们的尖端溶解型MA是一种有前途的透皮给药医疗设备。

更新日期：2020-04-23

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