This paper describes the isolation and characterization of 17 new and 12 known terpenoids from the fruit of Gardenia jasminoides. The structures of eight new triterpenoids and nine new monoterpenoids, including their absolute configurations, were defined by spectroscopic analysis in combination of quantum chemical electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and gauge-independent atomic orbital (GIAO) NMR calculations. The cytoprotective effects of the isolated compounds against lipopolysaccharide (LPS)-induced apoptosis in normal rat kidney tubule epithelioid (NRK 52e) cells were investigated in vitro. Compounds 10, 18, 20, 21, 24, and 26 exhibited significant protective effects with EC50 values from 14.2 nM to 1.6 μM.

中文翻译：

---

子果实中的肾脏保护性单萜和三萜类化合物。

本文介绍了从Garden子果实中分离和表征17种新的和12种已知的萜类化合物的特性。通过光谱分析结合量子化学电子圆二色性（ECD），振动圆二色性（VCD）和轨距无关原子轨道（GIAO）NMR定义了八种新的三萜和九种新的单萜的结构，包括其绝对构型计算。在体外研究了分离的化合物对脂多糖（LPS）诱导的正常大鼠肾小管上皮样细胞（NRK 52e）细胞凋亡的保护作用。化合物10、18、20、21、24和26表现出显着的保护作用，EC50值为14.2 nM至1.6μM。