A total of 21 different porphyrins, some of them closely related to the photosensitizer meta-tetrahydroxyphenylchlorin (m-THPC) with a varied degree of hydrophilic/lipophilic substitution were synthesized employing conventional porphyrin condensation procedures and modern functionalization via organolithium reagents. For 14 of them, the photodynamic therapy (PDT) related photophysical properties were determined in isotropic solution and in liposome membrane-model systems. The photophysical data indicate that the localization of m-THPC may be fine-tuned by carefully changing the substitution pattern.

中文翻译：

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亲水性与疏水性——改变与光敏剂 m-THPC 相关的卟啉的两亲结构

共 21 种不同的卟啉，其中一些与具有不同程度的亲水/亲油取代的光敏剂间四羟基苯二酚 (m-THPC) 密切相关，采用常规的卟啉缩合程序和通过有机锂试剂进行的现代功能化合成。对于其中的 14 个，在各向同性溶液和脂质体膜模型系统中确定了与光动力疗法 (PDT) 相关的光物理特性。光物理数据表明 m-THPC 的定位可以通过仔细改变替换模式来微调。