Mercury-Free Synthesis of Pincer [C^N^C]AuIII Complexes by an Oxidative Addition/CH Activation Cascade.,ChemSusChem

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Mercury-Free Synthesis of Pincer [C^N^C]AuIII Complexes by an Oxidative Addition/CH Activation Cascade.
ChemSusChem ( IF 7.5 ) Pub Date : 2020-03-24 , DOI: 10.1002/cssc.202000310
Daniel Eppel ₁ , Matthias Rudolph ₁ , Frank Rominger ₁ , A Stephen K Hashmi _{1,

2,

3}

Affiliation

Starting from the commercially available dimethyl sulfide-gold(I) chloride complex (DMSAuCl) and diazonium salts in the presence of 2,6-di-tert-butyl-4-methylpyridine as base, symmetric and unsymmetric [C^N^C]AuIII Cl complexes were synthesized in a selective, photosensitizer-free, photochemical reaction using blue LED light. This new protocol provides the first mercury-free synthesis of these types of pincer-complexes in moderate-to-excellent yields, starting from a readily available gold(I) precursor. Owing to the extraordinary properties of the target compounds, like excellent luminescence and high anticancer activities, the synthesis of such complexes is a highly active field of research, which might make its way to an industrial application. Owing to the disadvantages of the known protocols, especially the toxicity and the selectivity issues in the case of unsymmetric complexes, avoiding the use of mercury, should further accelerate this ongoing development.

中文翻译：

通过氧化加成/ CH活化级联反应，无汞合成钳型[C ^ N ^ C] AuIII配合物。

在2,6-二叔丁基-4-甲基吡啶为碱，对称和不对称的情况下，从市售的二甲基硫醚-氯化金（I）络合物（DMSAuCl）和重氮盐开始使用蓝光LED在无光敏剂的选择性光化学反应中合成了AuIII Cl络合物。这项新的协议从中等程度的金（I）前体开始，以中等至优异的产率提供了这些类型的钳形配合物的第一个无汞合成方法。由于目标化合物的非凡性能，例如出色的发光性和高抗癌活性，此类配合物的合成是一个非常活跃的研究领域，可能会走向工业应用。由于已知协议的缺点，

更新日期：2020-04-22

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